상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Antiatherosclerotic effects of Artemisia princeps Pampanini cv.Sajabal in LDL receptor deficient mice

 

LDL receptor 결핍마우스에서 사자발쑥의 항동맥경화효과

Authors 

Jong-Min HanM J KimSeung Hwa BaekS AnY Y JinH G ChungN I BaekM S ChoiK T LeeTae Sook Jeong

Publisher 

American Chemical Society

Issue Date 

2009

Citation 

Journal of Agricultural and Food Chemistry, vol. 57, no. 4, pp. 1267-1274

Keywords 

artemisia princeps pamp. cvatherosclerosisinflammationNF-κBoxidized LDLsajabal

Abstract 

Antiatherosclerotic effects of ethanolic extracts of Artemisia princeps Pampanini cv. Sajabal (ESJ) were investigated in low-density lipoprotein receptor deficient (LDLR -/-) mice. The Western dietinduced high levels of total cholesterol and triglyceride were similar in the ESJ and control groups. However, circulating oxidized LDL was significantly decreased in the ESJ group (p < 0.05). ESJ also markedly decreased aortic expression levels of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β), and reduced the aortic lesion formation and macrophage accumulation by 36.7% (p < 0.05) and 43% (p < 0.01) in the control group, respectively. Additionally, ESJ inhibited atherogenic properties with cytokine-induced surface expression of cell adhesion molecules, chemokines, and monocyte adhesion to the human umbilical vein endothelial cells (HUVECs), and simultaneously suppressed nuclear factor-κB (NF-κB) activation. These results suggest that ethanolic extracts of Artemisia princeps Pampanini cv. Sajabal contributes to the antiatherosclerotic and anti-inflammatory activities in LDLR -/- mice.

ISSN 

0021-8561

Link 

http://dx.doi.org/10.1021/jf802639y

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)