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Title 

Signal crosstalk between estrogen and peroxisome proliferator-activated receptor alpha on adiposity

Authors 

B H KimYoung Suk WonD Y KimB KimE Y KimM YoonG T Oh

Publisher 

Korean Society for Biochemistry and Molecular Biology

Issue Date 

2009

Citation 

BMB Reports, vol. 42, no. 2, pp. 91-95

Keywords 

estrogenperoxisome proliferator activated receptor alphasignal transductionestrogensPPAR alpha

Abstract 

Peroxisome proliferator-activated receptor alpha and estrogen are believed to be involved in metabolic changes leading to obesity. To test this relationship, we divided female wildtype and PPAR alpha-deficient mice fed on a high fat diet into the following groups: mock-operated, ovariectomized (OVX), and E(2)-treated. The visceral white adipose tissue and plasma cholesterol levels were increased significantly in wild type OVX and decreased in the E(2)-treated group, but interestingly not in PPAR alpha-deficient mice. The mRNA levels of lipoprotein lipase in adipose tissue were also increased in only wild type OVX and decreased significantly in E(2)-treated mice. These novel results suggest the possibility of signaling crosstalk between PPAR alpha and E2, causing obesity in vivo.

ISSN 

1976-6696

Link 

http://dx.doi.org/10.5483/BMBRep.2009.42.2.091

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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