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Title 

Diacylglycerol acyltransferase-inhibitory compounds from Erythrina senegalensis

Authors 

W K OhChul Ho LeeJ H SeoM Y ChungL CuiT FomumJ S KangHyun Sun Lee

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2009

Citation 

Archives of Pharmacal Research, vol. 32, no. 1, pp. 43-47

Keywords 

diacylglycerol acyltransferaseerythrina senegalensisprenylflavonoiddiacylglycerol acyltransferase inhibitorerythrina senegalensis extracterythrinadiacylglycerol o-acyltransferase

Abstract 

Inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT) is proposed to be a drug target for the treatment of obesity and type 2 diabetes. Bioassay-guided fractionation of the CH2Cl2-soluble extract of the stem bark of Erythrina senegalensis, using an in vitro DGAT enzyme assay, resulted in the isolation of eight known prenylflavonoids, 8-prenylleutone (1), auriculatin (2), erysenegalensein O (3), erysenegalensein D (4), erysenegalensein N (5), derrone (6), alpinumisoflavone (7), and 6,8-diprenylgenistein (8). Compounds 1, 2-4, 6, and 8 inhibited DGAT activity, with IC50 values ranging from 1.1 ± 0.3 to 15.1 ± 1.1 μg/mL. On the basis of the data obtained, we propose isoflavonoids with isoprenyl groups as a novel class of DGAT inhibitors.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-009-1116-2

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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