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Title 

Increased -1 ribosomal frameshifting efficiency by yeast prion-like phenotype [PSI+]

Authors 

H J ParkS J ParkDoo-Byoung OhS LeeY G Kim

Publisher 

Elsevier

Issue Date 

2009

Citation 

FEBS Letters, vol. 583, no. 4, pp. 665-669

Keywords 

-1 Ribosomal frameshifting[PSI+]slippery sequenceyeast prionphenotypeprionribosomal frameshiftingyeastframeshifting, ribosomal

Abstract 

Programmed -1 ribosomal frameshifting (-1RF) is usually regulated by a slippery sequence and an RNA secondary structure but can be affected by the slippery sequence combined with translational perturbation. Dramatic increases of -1RF efficiencies arise from the slippery sequences in [PSI+], an epigenetic modifier of translation termination fidelity. Curing of [PSI+] abolished such increases of -1RF efficiency. Enhanced -1RF frequency at the slippery sequences could be another physiological effect induced directly or indirectly by the perturbation of the translation process in [PSI+] cells.

ISSN 

0014-5793

Link 

http://dx.doi.org/10.1016/j.febslet.2009.01.015

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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