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Title 

Free radical scavenging and antielastase activities of flavonoids from the fruits of Thuja orientalis

Authors 

G H XuIn Ja RyooYoung Hee KimSoo-Jin ChooIck Dong Yoo

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2009

Citation 

Archives of Pharmacal Research, vol. 32, no. 2, pp. 275-282

Keywords 

ABTSDPPHelastaseflavonoidthuja orientalisfree radicalthuja orientalis extractantioxidant activityfruitstructure activity relation

Abstract 

Bioassay-guided fractionation of the MeOH extract of Thuja orientalis fruits using a DPPH (2,2-diphenyl-1-picrylhydrazyl) assay led to the isolation of 9 flavonoids: cupressuflavone (1), amentoflavone (2), robustaflavone (3), afzelin (4), (+)-catechin (5), quercitrin (6), hypolaetin 7-O-β- xylopyranoside (7), isoquercitrin (8) and myricitrin (9). Their chemical structures were determined by spectroscopic analyses. The free radical scavenging and human neutrophil elastase (HNE) inhibitory activities were evaluated for the isolated compounds. By DPPH scavenging assay, compounds 5, 6, 7, 8 and 9 showed anti-oxidant activities with IC50 values of 28.66, 31.19, 18.30, 26.63 and 15.10 μM, respectively. By ABTS [2,2′- azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt] scavenging assay, these compounds also exhibited potent anti-oxidant activities with IC50 values of 6.77, 13.96, 6.97, 22.79 and 9.96 μM, respectively. of note, compounds 1, 2 and 3 showed significant HNE inhibitory activities with IC50 values of 8.09, 1.27 and 1.33 μM, respectively.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-009-1233-y

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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