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Title 

Plasma pharmacokinetics and metabolism of the antitumour drug candidate 2'-benzoyloxycinnamaldehyde in rats

Authors 

Kiho LeeByoung-Mog KwonKang Jeon KimJ RyuSoo Jin OhKye Sook LeeM G KwonSong Kyu ParkJong Soon KangChang Woo LeeHwan Mook Kim

Publisher 

Informa Healthcare

Issue Date 

2009

Citation 

Xenobiotica, vol. 39, no. 3, pp. 255-265

Abstract 

The pharmacokinetics and metabolism of 2'-benzoyloxycinnamaldehyde (BCA) was characterized in male Sprague-Dawley rats as part of the preclinical evaluations for developing this compound as an antitumour agent. BCA was not detected in the plasma following either intravenous or oral dose, whereas its putative metabolites 2'-hydroxycinnamaldehyde (HCA) and o-coumaric acid were present at considerable levels. In separate pharmacokinetics studies, HCA exhibited a high systemic clearance and a large volume of distribution, whereas both pharmacokinetic parameters were much lower for o-coumaric acid. The terminal half-life of both metabolites was approximately 2 h. BCA was converted rapidly to HCA in rat serum, liver microsomes and cytosol in vitro; HCA was subsequently converted to o-coumaric acid in a quantitative manner only in the liver cytosol. In addition, the formation of o-coumaric acid was inhibited significantly by menadione, a specific inhibitor for aldehyde oxidase. Taken collectively, the results suggest that the rapid systemic clearance of HCA is likely due mainly to hepatic clearance occurring from aldehyde oxidase-catalysed biotransformation to o- coumaric acid. In conclusion, the present work demonstrates that the anticancer drug candidate BCA is highly likely to work as its active metabolite HCA in the body.

ISSN 

0049-8254

Link 

http://dx.doi.org/10.1080/00498250802650069

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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