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Title 

VDUP1 potentiates Ras-mediated angiogenesis via ROS production in endothelial cells

Authors 

Z H PiaoSuk Ran YoonM S KimJ H JeonS H LeeTae-Don KimHee Gu LeeKwang-Hee BaeJ K MinSang Jeon ChungMoonil KimYeesook ChoDoo-Byoung OhS Y ParkJ W ChungIn Pyo Choi

Publisher 

OMICS International

Issue Date 

2009

Citation 

Cellular and Molecular Biology, vol. 55, no. Suppl, pp. 1096-1103

Keywords 

ras proteinangiogenesiscell lineendothelium cellendothelial cellsras proteins

Abstract 

Vitamin D3 up-regulated protein 1 (VDUP1) is a tumor suppressor of which expression is reduced in a variety of cancer cells, and enforced expression inhibits the tumor cell proliferation. It inhibits the activity of thioredoxin, thus contributing cellular ROS generation. Since ROS is a critical factor for angiogenesis, we investigated the role of VDUP1 in angiogenesis and endothelial proliferation. The expression of VDUP1 was upregulated by overexpression of an oncogene, Ras. Enforced expression of VDUP1 increases ROS production and proliferation of Ras-overexpressing endothelial cells. Overexpression of VDUP1 increases the resistance to the anchorage-dependent cell death and tube formation of the Ras-overexpressing endothelial cell. In addition, the removal of ROS by ROS scavenger attenuates the effect of VDUP1 on tube formation. These results suggest that VDUP1 is involved in Ras-mediated angiogenesis via ROS generation in endothelial cells.

ISSN 

0145-5680

Link 

http://dx.doi.org/10.1170/125

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2018-08-01


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