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Title 

ATM blocks tunicamycin-induced endoplasmic reticulum stress

Authors 

L HeSun Ok KimO Song KwonSook-Jung JeongMin-Soo KimHee Gu LeeH OsadaM JungJong Seog AhnBo Yeon Kim

Publisher 

Elsevier

Issue Date 

2009

Citation 

FEBS Letters, vol. 583, no. 5, pp. 903-908

Keywords 

ataxia telangiectasia mutatedER stresstunicamycinX-box protein-1ATM proteinendoplasmic reticulum stress

Abstract 

Endoplasmic reticulum stress (ER-stress) is associated with ataxia telangiectasia mutated (ATM) gene. We present here conclusive data showing that ATM blocks ER-stress induced by tunicamycin or ionizing radiation (IR). X-box protein-1 (XBP-1) splicing, GRP78 expression and caspase-12 activation were increased by tunicamycin or IR in Atm-deficient AT5BIVA fibroblasts. Activation of caspase-12 and caspase-3 by tunicamycin was significantly reduced in cells transfected with wild-type Atm (AT5BIVA/wtATM). Atm knockdown by siRNA, however, noticeably elevated ER-stress and chemosensitivity to tunicamycin. In summary, we present substantial data demonstrating that ATM blocks the ER stress signaling associated with cancer cell proliferation.

ISSN 

0014-5793

Link 

http://dx.doi.org/10.1016/j.febslet.2009.02.002

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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