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Title 

Far upstream element-binding protein-1, a novel caspase substrate, acts as a cross-talker between apoptosis and the c-myc oncogene

Authors 

Mi JangByoung Chul ParkSunghyun KangSeung-Wook ChiS ChoSang Jeon ChungSang Chul LeeKwang-Hee BaeSung Goo Park

Publisher 

Nature Publishing Group

Issue Date 

2009

Citation 

Oncogene, vol. 28, no. 12, pp. 1529-1536

Keywords 

apoptosisC-MyccaspaseFBP-1FUSE

Abstract 

Far upstream element-binding protein-1 (FBP-1) binds to an upstream element of the c-myc promoter and regulates the c-myc mRNA level. Earlier, FBP-1 was identified as a candidate substrate of caspase-7. Here, we report that FBP-1 is cleaved by executor caspases, both in vitro and during apoptosis. Cleavage occurs at the caspase consensus site (DQPD 74) located within the classical bipartite nuclear localization signal sequence. In cells subjected to apoptotic stimuli, the caspase-mediated cleavage of FBP-1 leads to its decreased presence in the nucleus, concomitant with the marked downregulation of c-Myc and its various target proteins. By contrast, cells transfected with a non-cleavable mutant of FBP-1 (D74A) maintain higher levels of c-Myc and are protected from apoptosis. On the basis of these results, we suggest that the oncogenic potential of c-Myc is switched off after apoptosis induction as a consequence of the caspase-mediated cleavage of FBP-1.

ISSN 

0950-9232

Link 

http://dx.doi.org/10.1038/onc.2009.11

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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