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Title 

Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles

Authors 

W S ChoM ChoJinyoung JeongM ChoiH Y ChoB S HanS H KimH O KimYong Taik LimBong Hyun ChungJ Jeong

Publisher 

Elsevier

Issue Date 

2009

Citation 

Toxicology and Applied Pharmacology, vol. 236, no. 1, pp. 16-24

Keywords 

accumulationgold nanoparticlesinflammationintravenous injectionpharmacokineticsgold nanoparticleacute toxicitytoxicity testing

Abstract 

In general, gold nanoparticles are recognized as being as nontoxic. Still, there have been some reports on their toxicity, which has been shown to depend on the physical dimension, surface chemistry, and shape of the nanoparticles. In this study, we carry out an in vivo toxicity study using 13 nm-sized gold nanoparticles coated with PEG (MW 5000). In our findings the 13 nm sized PEG-coated gold nanoparticles were seen to induce acute inflammation and apoptosis in the liver. These nanoparticles were found to accumulate in the liver and spleen for up to 7 days after injection and to have long blood circulation times. In addition, transmission electron microscopy showed that numerous cytoplasmic vesicles and lysosomes of liver Kupffer cells and spleen macrophages contained the PEG-coated gold nanoparticles. These findings of toxicity and kinetics of PEG-coated gold nanoparticles may have important clinical implications regarding the safety issue as PEG-coated gold nanoparticles are widely used in biomedical applications.

ISSN 

0041-008X

Link 

http://dx.doi.org/10.1016/j.taap.2008.12.023

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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