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Title 

Anti-inflammatory and anti-asthmatic effects of resveratrol, a polyphenolic stilbene, in a mouse model of allergic asthma

Authors 

Mee Young LeeS KimOk-Kyoung KwonSei Ryang OhHyeong Kyu LeeKyung Seop Ahn

Publisher 

Elsevier

Issue Date 

2009

Citation 

International Immunopharmacology, vol. 9, no. 4, pp. 418-424

Keywords 

airway hyperresponsivenessasthmacytokineeosinophiliaresveratrolallergic asthmaanimal cellanimal experimentanimal modelanimal tissue

Abstract 

Asthma is an inflammatory disease of the airways, and the current focus in managing asthma is the control of inflammation. Resveratrol (3,4,5-trihydroxystilbene) is a polyphenolic stilbene found in the skins of red fruits, including grapes, that may be responsible for some of the health benefits ascribed to consumption of red wine. We investigated the suppressive effects of resveratrol on asthmatic parameters such as cytokine release, eosinophilia, airway hyperresponsiveness, and mucus hypersecretion, in an OVA-induced allergic mouse model of asthma. Resveratrol significantly inhibited increases in T-helper-2-type cytokines such as IL-4 and IL-5 in plasma and bronchoalveolar lavage fluid (BALF), and also effectively suppressed airway hyperresponsiveness, eosinophilia, and mucus hypersecretion, in the asthmatic mouse model. The efficacy of resveratrol was similar to that of dexamethasone, a glucocorticoid used as a positive control. These results suggest that resveratrol may have applications in the treatment of bronchial asthma.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2009.01.005

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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