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Title 

Characteristic of neuraminidase inhibitory xanthones from Cudrania tricuspidata

 

꾸지뽕나무 뿌리로 부터 뉴라미니데이즈 저해제인 잔톤화합물의 개발

Authors 

Young Bae RyuM J Curtis-LongJ W LeeJ H KimJ Y KimK Y KangWoo Song LeeK H Park

Publisher 

Elsevier

Issue Date 

2009

Citation 

Bioorganic & Medicinal Chemistry, vol. 17, no. 7, pp. 2744-2750

Keywords 

2vk6cudrania tricuspidataneuraminidasetime-dependentxanthonexanthone derivativemaclura tricuspidata

Abstract 

Natural polyphenolic compounds generally transpire to show relatively low inhibition against glycosidase including neuraminidase. In addition the inhibition modes of such compounds are rarely competitive. In this manuscript, a series of xanthone derivatives from Cudrania tricuspidata are shown to display nanomolar inhibitor activity against neuraminidase (EC 3.2.1.18) as well as competitive inhibition modes. Compound 8 bearing vicinal dihydroxy group on the A-ring displays nanomolar activity (IC50 = 0.08 ± 0.01 μM), a 200-fold increase in activity relative to that of the first reported xanthone-derived neuraminidase inhibitor, mangiferin (IC50 = 16.2 ± 4.2 μM). The 6,7-vicinal dihydroxy group plays a crucial role for inhibitory activity because compound 4, which has one of these hydroxyl groups prenylated was inactive (33% at 200 μM), whereas other compounds (1-3 and 6-8) showed nanomolar activity (0.08-0.27 μM) and competitive inhibition modes. Interestingly all inhibitors manifested enzyme isomerization inhibition against neuraminidase. The most potent inhibitor, compound 8 showed similar interaction with a transition-state analogue of neuraminic acid in active site.

ISSN 

0968-0896

Link 

http://dx.doi.org/10.1016/j.bmc.2009.02.042

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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