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Title 

Farnesyl protein transferase inhibitory components of Polygonum multiflorum

Authors 

Byoung-Mog KwonS H KimN I BaekS I LeeE J KimJ H YangB S ChaeJ H LeeH W ParkJ S ParkD K Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2009

Citation 

Archives of Pharmacal Research, vol. 32, no. 4, pp. 495-499

Keywords 

anthraquinone glycosidesFPTasepolygonaceaepolygonum multiflorum

Abstract 

The methanolic extract of the roots of Polygonum multiflorum (Polygonaceae) was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of two anthraquinone glycosides, as inhibitors of FPTase. These compounds inhibited the FPTase activity in a dose-dependent manner.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-009-1403-y

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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