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Title 

Fc fusion to Glucagon-like peptide-1 inhibits degradation by human DPP-IV, increasing its half-life in serum and inducing a potent activity for human GLP-1 receptor activation

Authors 

D M KimS H ChuSemi KimYoung Woo ParkS S Kim

Publisher 

Korean Society for Biochemistry and Molecular Biology

Issue Date 

2009

Citation 

BMB Reports, vol. 42, no. 4, pp. 212-216

Abstract 

The short in vivo half-life of GLP-1 prevents it from being used clinically. This short half-life occurs because GLP-1 is rapidly degraded by dipeptidyl peptidases such as DPP-IV. To overcome this obstacle, a GLP-1/Fc was constructed and evaluated to determine if it was degraded by DPP-IV and in serum. When the degradation of GLP-1/Fc by human DPP-IV and rabbit serum was compared with that of GLP-1 it was found to be reduced by approximately 5- and 4-fold, respectively. Furthermore, GLP-1/Fc showed a potent activity for human GLP-1 receptor activation (EC50 approximately 6 nM). Taken together, these results indicate that GLP-1/Fc may have an extended half-life in vivo that occurs as a result of inhibition of degradation by human DPP-IV. Due to the extended half life, GLP-1/Fc may be useful for clinical treatments.

ISSN 

1976-6696

Link 

http://dx.doi.org/10.5483/BMBRep.2009.42.4.212

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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