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Title 

Upregulation of the cycline kinase subunit CKS2 increases cell proliferation rate in gastric cancer

Authors 

Min Ah KangJong-Tae KimJ H KimS Y KimY H KimYoung Il YeomY LeeHee Gu Lee

Publisher 

Springer Verlag (Germany)

Issue Date 

2009

Citation 

Journal of Cancer Research and Clinical Oncology, vol. 135, no. 6, pp. 761-769

Keywords 

CDK1CKS2gastric cancerp53

Abstract 

Purpose: CKS2 was identified as an upregulated gene in gastric cancer via our DNA microarray. This study was to verify the upregulation of CKS2 in many gastric cancer patients and to examine the CKS2-mediated cellular response. Methods: CKS2 upregulation was analyzed using reverse transcriptase PCR, real-time PCR, and immunohistochemical and clinicopathological analyses. GFP-CKS2 or CKS2-siRNA was used to analyze the cellular localization and proliferation. Results: The strong upregulation of mRNA and protein levels of CKS2 was identified. In CKS2-overexpressing cells, tumor suppressor p53 and p21cip1 were downregulated and cell growth was increased. In contrast, CKS2-siRNA-transfected cells showed an increased tumor suppressor expression and decreased cell growth. Conclusions: We showed that CKS2 was significantly upregulated in gastric cancers and a high level of CKS2 was highly correlated with histologic tumor differentiation and pathological grade of the tumor size, lymph node, and metastasis stage. We suggest that the cell cycle regulator CKS2 might be deeply involved in gastric cancer progression.

ISSN 

0171-5216

Link 

http://dx.doi.org/10.1007/s00432-008-0510-3

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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