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Title 

Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum

Authors 

C SeoJ H SohnJong Seog AhnJ H YimH K LeeH Oh

Publisher 

Elsevier

Issue Date 

2009

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 19, no. 10, pp. 2801-2803

Keywords 

depsidoneslichen metabolitesnon-competitive inhibitorsprotein tyrosine phosphatase 1B (PTP1B)stereocaulon alpinum

Abstract 

Seven phenolic lichen metabolites (1-7) have been isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum by various chromatographic methods. The structures of these compounds were determined mainly by analysis of NMR spectroscopic data. A depsidone-type compound, lobaric acid (1) and two pseudodepsidone-type compounds, 2 and 3, exhibited potent inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 0.87 μM, 6.86 μM, and 2.48 μM, respectively. Kinetic analyses of PTP1B inhibition by compounds 1 and 2 suggested that these compounds inhibited PTP1B activity in a non-competitive manner.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2009.03.108

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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