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Title 

Inhibitory effects of quercetin 3-rhamnoside on influenza A virus replication

Authors 

H J ChoiJ H SongK S ParkDur Han Kwon

Publisher 

Elsevier

Issue Date 

2009

Citation 

European Journal of Pharmaceutical Sciences, vol. 37, no. 3, pp. 329-333

Keywords 

antiviral activityhouttuynia cordatainfluenzaquercetin 3-rhamnoside (Q3R)

Abstract 

Influenza viruses cause significant morbidity and mortality in humans through epidemics or pandemics. The lack of effective therapeutical treatment underlines the importance of research for new antiviral compounds. Flavonoids widely exist in the plant kingdom, and their antiviral activities against various viruses have been recently reported. In this study, the anti-influenza A/WS/33 virus of quercetin 3-rhamnoside (Q3R) from Houttuynia cordata was evaluated using a cytopathic effect (CPE) reduction method, the assay results demonstrated that Q3R possessed strong anti-influenza A/WS/33 virus reducing the formation of a visible CPE. Q3R also did inhibit virus replication in the initial stage of virus infection by indirect interaction with virus particles. However, oseltamivir has relative weaker efficacy compared to Q3R. Therefore, these findings provide important information for the utilization of Q3R for influenza treatment.

ISSN 

0928-0987

Link 

http://dx.doi.org/10.1016/j.ejps.2009.03.002

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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