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Title 

Human ZNF312b promotes the progression of gastric cancer by transcriptional activation of the K-ras gene

Authors 

In-Seong SongNang Su OhH T KimGa-Hee HaSo-Young JeongJ M KimD I KimHyang Sook YooC H KimNam-Soon Kim

Publisher 

American Association for Cancer Research

Issue Date 

2009

Citation 

Cancer Research, vol. 69, no. 7, pp. 3131-3139

Keywords 

KRAS protein, humanmitogen activated protein kinaseRas proteincancer staginggene expression regulationgenetic transfectiongeneticshumanoncogene rasdisease progression

Abstract 

Gastric cancer ranks second among the most common causes of cancer deaths worldwide. Recent studies reported target molecules that are candidates for new therapeutic interventions; however, their molecular mechanism has not been clearly defined. In this study, we found that ZNF312b plays a role in tumor progression and metastasis in gastric cancer via transcriptional activation of the K-ras oncogene. ZNF312b seems to be specifically overexpressed in gastric cancer tissues and cell lines. The overexpression of ZNF312b induces cancer-like phenotypes, including accelerated proliferation and increased tumor masses in nude mice, which are completely reversed by its knockdown in gastric cancer cell lines, implying direct involvement in gastric tumor progression. From analyses using deletion mutants of ZNF312b and K-ras promoter-driven luciferase reporters, we found that it translocates into the nucleus via the proline-rich domain of its COOH terminus to activate transcription of the K-ras gene, resulting in an enhancement of the extracellular signal-regulated kinase signaling pathway that governs cell proliferation. Taken together, these results suggest that ZNF312b contributes to the promotion of gastric cancer by triggering K-ras oncogene expression. The current study is the first to report that ZNF312b, a novel transcription factor, was associated with tumorigenicity of gastric cancer. This might be a valuable target that could provide new insight into the development of new therapeutic modalities for patients with gastric cancer.

ISSN 

0008-5472

Link 

http://dx.doi.org/10.1158/0008-5472.CAN-08-2240

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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