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Title 

Isolation of betulinic acid, its methyl ester and guaiane sesquiterpenoids with protein tyrosine phosphatase 1B inhibitory activity from the roots of Saussurea lappa C.B.Clarke

Authors 

J Y ChoiM NaI H HwangS H LeeEun Young BaeBo Yeon KimJong Seog Ahn

Publisher 

MDPI

Issue Date 

2009

Citation 

Molecules, vol. 14, no. 1, pp. 266-272

Keywords 

betulinic acidbetulinic acid methyl esterdehydrocostuslactonemokko lactoneprotein tyrosine phosphatase 1Bsaussurea lappa C.B.Clarke

Abstract 

Activity-guided fractionation of a MeOH extract of the roots of Saussurea lappa C.B.Clarke (Compositae), using an in vitro protein tyrosine phosphatase 1B (PTP1B) inhibition assay, led to the isolation of four active constituents: betulinic acid (1), betulinic acid methyl ester (2), mokko lactone (3) and dehydrocostuslactone (4), along with nine inactive compounds. Our findings indicate that betulinic acid (1) and its methyl ester 2, as well as the two guaiane sesquiterpenoids 3 and 4 are potential lead moieties for the development of new PTP1B inhibitors.

ISSN 

1420-3049

Link 

http://dx.doi.org/10.3390/molecules14010266

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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