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Title 

Anti-inflammatory activity of (-)-aptosimon isolated from Daphne genkwa in RAW264.7 cells

 

압토시몬의 항염효과

Authors 

M Y LeeB Y ParkOk-Kyoung KwonJi Eun YukSei Ryang OhHui-Seong KimHyeong Kyu LeeKyung Seop Ahn

Publisher 

Elsevier

Issue Date 

2009

Citation 

International Immunopharmacology, vol. 9, no. 7, pp. 878-885

Keywords 

(-)-aptosimonanti-inflammatoryCOX-2IL-13IL-4iNOS

Abstract 

In the present study, we investigated that (-)-aptosimon, isolated from flower buds of Daphne genkwa, inhibited cyclooxygenase-2 (COX-2) and inducible nitric oxide (NO) synthase (iNOS) expression in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Similarly, (-)-aptosimon suppressed tumor necrosis factor (TNF)-α production. Our results clearly indicated that (-)-aptosimon inhibited LPS-induced nuclear factor-κB (NF-κB) activation, by preventing degradation of the inhibitor kappa B-alpha (IκB-α). (-)-Aptosimon also inhibited interleukin-4 (IL-4) and interleukin-13 (IL-13) production in ConA-induced splenocytes. In conclusion, the anti-inflammatory effects of (-)-aptosimon are attributed to the suppression of pro-inflammatory cytokines and mediators by blocking NF-κB activation. These data suggest that (-)-aptosimon as a potential therapeutic agent for inflammation-associated disorders.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2009.03.012

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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