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Title 

Comparison of exon-boundary old and young domains during metazoan evolution

Authors 

ByungUk Lee

Publisher 

Korea Genome Organization

Issue Date 

2009

Citation 

Genomics & Informatics, vol. 7, no. 2, pp. 131-135

Keywords 

domain mobility and versatilityexon shufflingold and young domains

Abstract 

Domains are the building blocks of proteins. Exon shuffling is an important mechanism accounting for combination of a limited repertoire of protein domains in the evolution of multicellular species. A relative excess of domains encoded by symmetric exons in metazoan phyla has been presented as evidence of exon shuffling, and symmetric domains can be divided into old and new domains by determining the ages of the domains. In this report, we compare the spread, versatility, and subcellular localization of old and new domains by analyzing eight metazoan genomes and their respective annotated proteomes. We found that new domains have been expanding as multicellular organisms evolved, and this expansion was principally because of increases in class 1-1 domains amongst several classes of domain families. We also found that younger domains have been expanding in membranes and secreted proteins along with multi-cellular organism evolution. In contrast, old domains are located mainly in nuclear and cytoplasmic proteins. We conclude that the increasing mobility and versatility of new domains, in contrast to old domains, plays a significant role in metazoan evolution, facilitating the creation of secreted and transmembrane multidomain proteins unique to metazoa.

ISSN 

1598-866X

Link 

http://dx.doi.org/10.5808/GI.2009.7.2.131

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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