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Title 

Synthesis of a novel series of imidazo[1,2-α]pyridines as Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors

Authors 

Y JinMun Chual RhoK GajulapatiH Y JungS K BoovanahalliJ H LeeG Y SongJ H ChoiYoung Kook KimKyeong LeeY Choi

Publisher 

The Korean Chemical Society

Issue Date 

2009

Citation 

Bulletin of the Korean Chemical Society, vol. 30, no. 6, pp. 1297-1304

Keywords 

imidazo[1,2-α]pyridines, acyl CoAcholestrol acyl transferase (ACAT)HepG2 cells, structure-activity relationship

Abstract 

A novel series of imidazo[1,2-α]pyridines was designed, synthesized, and tested for their ability to inhibit acyl-CoA:cholesterol acyltransferase. Preliminary lead optimization efforts resulted in the identification of ACAT inhibitors represented by analogues 5b, 5c, 6a, 6c, 7b, and 7c. The ACAT inhibitory activity of these compounds was further established by potent inhibition of cholesteryl ester formation in HepG2 cells by a representative analogue 7b.

ISSN 

0253-2964

Link 

http://dx.doi.org/10.5012/bkcs.2009.30.6.1297

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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