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Title 

Antifungal activity of CHE-23C, a dimeric sesquiterpene from Chloranthus henryi

Authors 

Yon Mi LeeJae Sun MoonB S YunK D ParkG J ChoiJ C KimS H LeeSung Uk Kim

Publisher 

American Chemical Society

Issue Date 

2009

Citation 

Journal of Agricultural and Food Chemistry, vol. 57, no. 13, pp. 5750-5755

Keywords 

chloranthus henryiCHE-23Cantifungal activityphytophthora infestanspuccinia recondita

Abstract 

An antifungal compound was isolated from methanol extracts of stems and roots of Chloranthus henryi Hemsl. using ethyl acetate extraction and various chromatographic techniques. On the basis of spectroscopic analyses including mass and various NMR, the structure of the compound was identified as a dimeric sesquiterpene, CHE-23C. The compound showed potent antifungal activities (MICs = 1-32 μg/mL) in vitro against various phytopathogenic fungi such as Alternaria kikuchiana, Botrytis cinerea, Colletotrichum lagenarium, Magnaporthe grisea, Pythium ultimum, and Phytophthora infestans. In particular, it exhibited 91 and 100% disease-control activity in vivo against tomato late blight (P. infestans) and wheat leaf rust (Puccinia recondita) at concentrations of 33 and 100 μg/mL, respectively. The disease-control activity of this compound was stronger than that of the commercially available fungicide chlorothalonil, but weaker than that of dimethomorph. Therefore, the compound might serve as an interesting lead to develop effective antifungal agents.

ISSN 

0021-8561

Link 

http://dx.doi.org/10.1021/jf900674y

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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