상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Analysis of trans-splicing transcripts in embryonic stem cell

 

배아줄기세포에서 트랜스 스플라이싱 전사체의 분석

Authors 

H S HaJae Won HuhDae Soo KimS J ParkJ H BaeK AhnS E YunH S Kim

Publisher 

Korean Society of Life Science

Issue Date 

2009

Citation 

Journal of Life Science, vol. 19, no. 4, pp. 549-552

Keywords 

fusion genetrans-splicingbioinformaticsgenetic mutationchromosome analysis

Abstract 

Genetic mutations by gene fusion result from chromosomal rearrangement, trans-splicing, and intergenic splicing. Trans-splicing is a phenomenon in which two pre-mRNAs grow together into one. We analyzed the trans-splicing products in embryonic stem cells. By using bioinformatic tools, 70 trans-splicing transcripts were identified. They are classified into 6 types according to fusion pattern: 5'UTR-5'UTR, 5'UTR-3'UTR, 3'UTR-3'UTR, 5'UTR-CDS, 3'UTR-CDS, CDS-CDS. The fusion products are more abundant in CDS regions than in UTR regions, which contain multiple intron numbers. Chromosome analysis showing gene fusion via trans-splicing indicated that chromosomes 17 and 19 were activated. These data are of great use for further studies in relation to fusion genes and human diseases.

ISSN 

1229-1552

Link 

http://dx.doi.org/10.5352/JLS.2009.19.4.549

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)