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Title 

A peroxisome proliferator-activated receptor-gamma agonist and other constituents from Chromolaena odorata

Authors 

N T DatKyeong LeeYoung-Soo HongY H KimC V MinhJung Joon Lee

Publisher 

Georg Thieme Verlag

Issue Date 

2009

Citation 

Planta Medica, vol. 75, no. 8, pp. 803-807

Keywords 

chromolaena odorataasteraceae(9S,13R).12.oxo.phytodienoicchromomoric acid GPPAR-γ

Abstract 

Peroxisome proliferator-activated receptors (PPARs) are key regulators of lipid and glucose metabolism and have become important therapeutic targets for various diseases. The phytochemical investigation of the chloroform-soluble extract of Chromolaena odorata led to the isolation of a PPAR-γ agonist, (9S,13R)-12-oxo-phytodienoic acid (1), together with 12 other compounds. The structures of chromomoric acid G (2), a new dehydrogenated derivative of 1, and chromolanone (3) were elucidated based on spectroscopic methods. Compound 1 showed a significant effect on PPAR-γ activation in comparison with rosiglitazone. However, compound 2 was inactive, suggesting that the dehydrogenation of the prostaglandin-like structure in 1 abrogates its PPAR-γ agonistic activity.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-0029-1185386

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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