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Title 

Protective effect of Hovenia dulcis thumb leaves extract on hepatic injury induced by benzo(a)pyrene in mice

 

헛개나무 잎 추출물의 벤조피렌 유발 간 독성에 대한 보호효과

Authors 

S H ParkE Y ChangJong Sun ChangK Y Yoon

Publisher 

Korean Society for Food Science & Nutrition

Issue Date 

2009

Citation 

Journal of Korean Society for Food Science & Nutrition, vol. 38, no. 5, pp. 569-573

Keywords 

Hovenia dulcis Thumb leavesbenzo(α)pyrenehepatotoxicity

Abstract 

This study was carried out to investigate the protective effect of Hovenia dulcis Thumb leaves extract on liver damage in benzo(α)pyrene (B(α)P)-treated mice. Hovenia dulcis Thumb leaves methanol extract was intraperitoneally injected once daily for 5 successive days, followed by treatment with B(α)p. The elevated activities of serum aminotransferase and hepatic cytochrome P450 by B(α)p were decreased by pretreatment with Hovenia dulcis Thumb leaves extract. Hovenia dulcis Thumb leaves extract also significantly prevented the elevation of hepatic malondialdehyde content and depletion of glutathione content induced by B(α)P. In addition, the increased activities of superoxide dismutase, catalase and glutathione peroxidase after B(α)P-treatment were decreased. On the other hand, glutathione S-transferase activity was increased by pretreatment with Hovenia dulcis Thumb leaves extract. These results suggest that Hovenia dulcis Thumb leaves extract have a protective effect on liver damage by B(α)P through the mechanisms of decreasing lipid peroxide and activities of free radical generating enzymes.

ISSN 

1226-3311

Link 

http://dx.doi.org/10.3746/jkfn.2009.38.5.569

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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