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Title 

Phenolic glycosides from Alangium salviifolium leaves with inhibitory activity on LPS-induced NO, PGE2, and TNF-α production

Authors 

T M HungN H DangJ C KimJ S ChoiHyeong Kyu LeeB S Min

Publisher 

Elsevier

Issue Date 

2009

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 19, no. 15, pp. 4389-4393

Keywords 

Alangium salviifoliumAlangiaceaePhenolic glycosidesAnti-inflammatory

Abstract 

Three new phenolic glycosides, salviifosides A-C (1-3), and three known compounds salicin (4), kaempferol (5), and kaempferol 3-O-β-D-glucopyranoside (6) were isolated from the leaves of Alangium salviifolium (L.f.) Wangerin (Alangiaceae). The structures of the new metabolites were determined on the basic of spectroscopic analyses including two dimensional NMR. The anti-inflammatory activities of new compounds (1-3) were investigated on lipopolysaccharide (LPS)-induced murine macrophage cells line, RAW 264.7. Salviifoside B (2) potentially inhibits the productions of nitric oxide (NO), prostaglandin E2 (PGE2), and tumor necrosis factor-a (TNF-α).

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2009.05.070

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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