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Title 

Processed short neuropeptide F peptides regulate growth through the ERK-insulin pathway in Drosophila melanogaster

Authors 

Kyu-Sun LeeSeung Hyn HongAe Kyung KimSeong Kyu JooO Y KwonKweon Yu

Publisher 

Elsevier

Issue Date 

2009

Citation 

FEBS Letters, vol. 583, no. 15, pp. 2573-2577

Keywords 

DrosophilaERK-insulin pathwayGrowthProcessed peptideShort neuropeptide F

Abstract 

The Drosophila sNPF gene regulates growth through the ERK-insulin pathway. sNPF encodes a precursor protein that is processed and produces biologically active sNPF peptides. However, the functions of these peptides are not known. In Drosophila neuronal cells in culture and in flies in vivo, sNPF1 and sNPF2 activated the ERK-insulin pathway and regulated body growth. In addition, the sNPF precursor and the processed sNPF peptide were co-localized in the neurons of the central nervous system. These results indicate that sNPF1 and sNPF2 peptides processed from the sNPF precursor are sufficient for regulating body growth through the ERK-insulin pathway in Drosophila.

ISSN 

0014-5793

Link 

http://dx.doi.org/10.1016/j.febslet.2009.07.024

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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