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Title 

C5-Modified nucleosides exhibiting anticancer activity

Authors 

Y S LeeS M ParkHwan Mook KimSong Kyu ParkKiho LeeChang Woo LeeB H Kim

Publisher 

Elsevier

Issue Date 

2009

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 19, no. 16, pp. 4688-4691

Keywords 

AnticancerNucleosideTriazoleIsoxazoleCycloaddition

Abstract 

We describe (i) a simple method for the synthesis of C5-modified nucleosides from 5-iodo-20-deoxyuridine and (ii) their activity against six types of human cancer cell lines (HCT15, MM231, NCI-H23, NUGC-3, PC-3, ACHN). We generated nitrile oxides in situ from oximes using a commercial bleaching agent; their cycloadditions with 5-ethynyl-20-deoxyuridine yielded isoxazole derivatives possessing activity against the cancer cell lines. We synthesized several azides from benzylic bromides and their click reactions with 5-ethynyl-20-deoxyuridine provided triazole derivatives.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2009.06.072

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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