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Title 

CIIA induces the epithelial-mesenchymal transition and cell invasion

Authors 

S Y HanH S HwangJ S ChaeYang suk jinJ H YoonYoung Il YeomE J Choi

Publisher 

Elsevier

Issue Date 

2009

Citation 

Biochemical and Biophysical Research Communications, vol. 387, no. 3, pp. 548-552

Keywords 

CIIAEpithelial.mesenchymal transitionMigrationInvasionClaudin-1

Abstract 

Epithelial.mesenchymal transition (EMT) and the acquisition of invasive potential are key events in tumor progression. We now show that CIIA, originally identified as an anti-apoptotic protein, induces the EMT and promotes cell migration and invasion. Ectopic expression of CIIA induced down-regulation of E-cadherin and claudin-1 as well as up-regulation of N-cadherin in MDCK cells. It also disrupted the differentiated epithelial morphology of MDCK cells grown in three-dimensional Matrigel cultures as well as increased the migration and invasion of MDCK cells in vitro. Furthermore, depletion of endogenous CIIA by RNA interference inhibited the migration and invasion of HeLa cells, and this inhibition was abolished by RNA interference-mediated depletion of claudin-1. These results suggest that CIIA functions as an inducer of cell invasion, and this effect is mediated, at least in part, through down-regulation of claudin-1.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2009.07.050

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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