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Title 

Fingerprinting differentiation of Astragalus membranaceus roots according to ages using 1H-NMR spectroscopy and multivariate statistical analysis

Authors 

Y S ShinK H BangD S InJ S SungS Y KimB C KuSuk Weon KimD LeeH K Choi

Publisher 

Korean Society of Applied Pharmacology

Issue Date 

2009

Citation 

Biomolecules & Therapeutics, vol. 17, no. 2, pp. 133-137

Keywords 

1H NMR spectroscopyAstragalus membranaceusCanonical discriminant analysisFingerprinting analysisPrincipal component analysis

Abstract 

The root of Astragalus membranaceus is a traditional folk medicine that has been used for many therapeutic purposes in Asia. It reportedly acts as an immunostimulant, tonic, hepatoprotective, diuretic, antidiabetic, analgesic, expectorant, sedative, and anticancer drug. In this study, metabolomic profiling was applied to the roots of A. membranaceus of different ages using NMR coupled with two multivariate statistical analysis methods: such as principal components analysis (PCA) and canonical discriminant analysis (CDA). This allowed various metabolites to be assigned in NMR spectra, including γ-aminobutyric acid (GABA), aspartic acid, succinic acid, glutamic acid, glutamine, N-acetyl aspartic acid, acetic acid, arginine, alanine, threonine, lactic acid, and valine. The score plot from PCA and also CDA allowed a clear separation between samples according to age.

ISSN 

1976-9148

Link 

http://dx.doi.org/10.4062/biomolther.2009.17.2.133

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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