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Title 

A comparison of gene expression profiles between primary human AML cells and therapy-related AML cells

Authors 

Y H KimH S KimJ HwangJ LeeS KimS Y ParkKyu Tae ChangK S KimZ Y RyooS Lee

Publisher 

Korean Society of Applied Pharmacology

Issue Date 

2008

Citation 

Biomolecules & Therapeutics, vol. 16, no. 4, pp. 431-436

Keywords 

Gene expressionSAGETherapy-related AML

Abstract 

To identify genes whose expression correlated with biological features of therapy-related AML (t-AML), we analyzed the expression profiles of de novo AML t(9; 11) and t-AML t(9; 11) bone marrow samples using previously published SAGE data. Three-hundred twenty-nine transcripts that satisfied statistical (P<0.05) and magnitude-of-change (≥ 4-fold) criteria were identified as differentially expressed between de novo AML t(9; 11) cells. of these transcripts, 301 (91%) matched known genes or ESTs and were classified according to functional categories (http://david.abcc.ncifcrf.gov/). The majority of differentially expressed genes in t-AML t(9; 11) were involved in the regulation of biological and metabolic processes. Especially prominent among these were genes related to immune and drug responses. These results establish a framework for developing new drugs for the treatment of t-AML.

ISSN 

1976-9148

Link 

http://dx.doi.org/10.4062/biomolther.2008.16.4.431

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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