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Title 

Reduced formation of advanced glycation endproducts via interactions between glutathione peroxidase 3 and dihydroxyacetone kinase 1

Authors 

Hana LeeSeung-Wook ChiP Y LeeSunghyun KangS ChoC K LeeKwang-Hee BaeByoung Chul ParkSung Goo Park

Publisher 

Elsevier

Issue Date 

2009

Citation 

Biochemical and Biophysical Research Communications, vol. 389, no. 1, pp. 177-180

Keywords 

Advanced glycation endproductDihydroxyacetoneDihydroxyacetone kinase 1Glutathione peroxidase 3Oxidative stress

Abstract 

Dihydroxyacetone (DHA) induces the formation of advanced glycation endproducts (AGEs), which are involved in several diseases. Earlier, we identified dihydroxyacetone kinase 1 (Dak1) as a candidate glutathione peroxidase 3 (Gpx3)-interacting protein in Saccharomyces cerevisiae. This finding is noteworthy, as no clear evidence on the involvement of oxidative stress systems in DHA-induced AGE formation has been found to date. Here, we demonstrate that Gpx3 interacts with Dak1, alleviates DHA-mediated stress by upregulating Dak activity, and consequently suppresses AGE formation. Based on these results, we propose that defense systems against oxidative stress and DHA-induced AGE formation are related via interactions between Gpx3 and Dak1.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2009.08.116

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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