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Title 

Protective mechanisms of 3-caffeoyl, 4-dihydrocaffeoyl quinic acid from Salicornia herbacea against tert-butyl hydroperoxide-induced oxidative damage

Authors 

Y P HwangH J YunHyo Kon ChunY C ChungH K KimM H JeongT R YoonH G Jeong

Publisher 

Elsevier

Issue Date 

2009

Citation 

Chemico-Biological Interactions, vol. 181, no. 3, pp. 366-376

Keywords 

3-Caffeoyl4-Dihydrocaffeoyl quinic acidCytoprotectionHeme oxygenase-1Oxidative stressSalicornia herbaceatert-Butyl hydroperoxide

Abstract 

Salicornia herbacea has been used as a folk medicine for disorders such as constipation, obesity, diabetes, and cancer. Recent studies have shown that S. herbacea has antioxidative, anti-inflammatory, immunomodulatory, antihyperglycemic, and antihyperlipidemic activities. In the present work, we investigated the protective effects of the chlorogenic acid derivative, 3-caffeoyl, 4-dihydrocaffeoyl quinic acid (CDCQ), which was isolated from S. herbacea, against tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity in Hepa1c1c7 cells. Pretreatment of Hepa1c1c7 cells with CDCQ significantly reduced t-BHP-induced generation of ROS, caspase-3 activation, and subsequent cell death. Also, CDCQ up-regulated heme oxygenase-1 (HO-1) expression, which conferred cytoprotection against oxidative injury induced by t-BHP. Moreover, CDCQ-induced nuclear translocation of the transcription factor NF-E2-related factor 2 (Nrf2), which is upstream of CDCQ-induced HO-1 expression, and PI3K/Akt activation, a pathway that is involved in induced Nrf2 nuclear translocation. Taken together, these results suggest that the protective effects of CDCQ against t-BHP-induced hepatotoxicity may be due, at least in part, to its ability to scavenge ROS and to regulate the antioxidant enzyme HO-1 via the PI3K/Akt-Nrf2 signaling pathways.

ISSN 

0009-2797

Link 

http://dx.doi.org/10.1016/j.cbi.2009.07.017

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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