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Title 

Oleanane-type triterpenoids from Aceriphyllum rossii and their cytotoxic activity

Authors 

L T K VanT M HungP T ThuongT M NgocJ C KimH S JangX F CaiSei Ryang OhB S MinM H WooJ S ChoiHyeong Kyu LeeK Bea

Publisher 

American Chemical Society

Issue Date 

2009

Citation 

Journal of Natural Products, vol. 72, no. 8, pp. 1419-1423

Abstract 

The hexane-soluble fraction of the roots of Aceriphyllum rossii was used to isolate seven new oleanane-type triterpenoids, aceriphyllic acids C-I (1-7), together with seven known triterpenoids. The structures of aceriphyllic acids C-I were determined as 3α-hydroxyolean-12-en-23,29-dioic acid (1), 3β-hydroxyolean-12-en-23,29-dioic acid (2), 3β,23-dihydroxyolean-12- en-29-oic acid (3), 3R-O-acetylolean-12-en-23,27-dioic acid (4), 3α-O-caffeoylolean-12-en-27-oic acid (5), 3α-O-acetylolean-12-en-23, 29-dioic acid (6), and 3α-hydroxyolean-12-en-23-al-27-oic acid (7) by spectroscopic analyses. In the evaluation of the in vitro cytotoxicity of these compounds against the MCF-7 and LLC cancer cell lines, compounds 10 and 13 exhibited cytotoxic activity against the LLC cancer cell line with IC 50 values of 7.63 and 6.56 μM, respectively.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/np900273z

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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