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Title 

Pseudomonas aeruginosa eliminates natural killer cells via phagocytosis-induced apoptosis

Authors 

J W ChungZ H PiaoSuk Ran YoonMi-Sun KimM JeongSuk Hyung LeeJeong Ki MinJae Wha KimY H ChoJ C KimJ K AhnK E KimIn Pyo Choi

Publisher 

Public Library of Science

Issue Date 

2009

Citation 

Plos Pathogens, vol. 5, no. 8, pp. 1000561-1000561

Abstract 

Pseudomonas aeruginosa (PA) is an opportunistic pathogen that causes the relapse of illness in immunocompromised patients, leading to prolonged hospitalization, increased medical expense, and death. In this report, we show that PA invades natural killer (NK) cells and induces phagocytosis-induced cell death (PICD) of lymphocytes. In vivo tumor metastasis was augmented by PA infection, with a significant reduction in NK cell number. Adoptive transfer of NK cells mitigated PA-induced metastasis. Internalization of PA into NK cells was observed by transmission electron microscopy. In addition, PA invaded NK cells via phosphoinositide 3-kinase (PI3K) activation, and the phagocytic event led to caspase 9-dependent apoptosis of NK cells. PA-mediated NK cell apoptosis was dependent on activation of mitogen-activated protein (MAP) kinase and the generation of reactive oxygen species (ROS). These data suggest that the phagocytosis of PA by NK cells is a critical event that affects the relapse of diseases in immunocompromised patients, such as those with cancer, and provides important insights into the interactions between PA and NK cells.

ISSN 

1553-7366

Link 

http://dx.doi.org/10.1371/journal.ppat.1000561

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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