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Title 

Discovery of novel and potent Cdc25 phosphatase inhibitors based on the structure-based de novo design

Authors 

H ParkSuk-Kyeong JungYoung Jae BahnDae Gwin JeongS E RyuSeung Jun Kim

Publisher 

The Korean Chemical Society

Issue Date 

2009

Citation 

Bulletin of the Korean Chemical Society, vol. 30, no. 6, pp. 1313-1316

Keywords 

Anticancer agentsCdc25 phosphataseDe novo designInhibitor

Abstract 

Cdc25 phosphatases have been considered as attractive drug targets for anticancer therapy due to the correlation of their overexpression with a wide variety of cancers. We have been able to identify five novel Cdc25 phosphatase inhibitors with micromolar activity by means of a structure-based de novo design method with a known inhibitor scaffold. Because the newly discovered inhibitors are structurally diverse and have desirable physicochemical properties as a drug candidate, they deserve further investigation as anticancer drugs. The differences in binding modes of the identified inhibitors in the active sites of Cdc25A and B are addressed in detail.

ISSN 

0253-2964

Link 

http://dx.doi.org/10.5012/bkcs.2009.30.6.1313

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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