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Title 

Nanogap biosensors for electrical and label-free detection of biomolecular interactions

Authors 

Sang Gyu KimHyeon Min JoH J ParkDo-Hyeong GwonJeong Min LeeBong Hyun Chung

Publisher 

Institute of Physics

Issue Date 

2009

Citation 

Nanotechnology, vol. 20, no. 45, pp. 455502-455508

Abstract 

We demonstrate nanogap biosensors for electrical and label-free detection of biomolecular interactions. Parallel fabrication of nanometer distance gaps has been achieved using a silicon anisotropic wet etching technique on a silicon-on-insulator (SOI) wafer with a finely controllable silicon device layer. Since silicon anisotropic wet etching resulted in a trapezoid-shaped structure whose end became narrower during the etching, the nanogap structure was simply fabricated on the device layer of a SOI wafer. The nanogap devices were individually addressable and a gap size of less than 60nm was obtained. We demonstrate that the nanogap biosensors can electrically detect biomolecular interactions such as biotin/streptavidin and antigen/antibody pairs. The nanogap devices show a current increase when the proteins are bound to the surface. The current increases proportionally depending upon the concentrations of the molecules in the range of 100 fgml-1-100 ngml-1 at 1V bias. It is expected that the nanogap developed here could be a highly sensitive biosensor platform for label-free detection of biomolecular interactions.

ISSN 

0957-4484

Link 

http://dx.doi.org/10.1088/0957-4484/20/45/455502

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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