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Title 

Adipocyte culture medium stimulates invasiveness of MDA-MB-231 cell via CCL20 production

Authors 

K Y KimA BaekY S ParkM Y ParkJ H KimJ S LimM S LeeSuk Ran YoonHee Gu LeeY YoonD Y YoonY Yang

Publisher 

Spandidos Publications

Issue Date 

2009

Citation 

Oncology Reports, vol. 22, no. 6, pp. 1497-1504

Keywords 

AdipocytesBreast cancerCCL20

Abstract 

We explored whether adipocyte culture medium affects the secreted chemokine profile of tumor cells, because adipocytes stimulate progression or metastasis of breast cancer cells, and chemokines secreted from tumor cells are involved in these processes. CCL20 expression was dramatically increased, and an NF-κB blocker completely inhibited adipocyte culture medium-induced CCL20 expression in MDA-MB-231 cells. We showed that adipocyte culture medium increased the production of TNF-α in MDA-MB-231 cells, which stimulated CCL20 expression in an autocrine fashion. Our data also showed that CCL20 increased the migration and invasiveness of MDA-MB-231 cells, but did not affect the proliferation of these cells.

ISSN 

1021-335X

Link 

http://dx.doi.org/10.3892/or_00000593

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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