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Title 

Clitocybin D acid, a novel human neutrophil elastase inhibitor from the culture broth of Clitocybe aurantiaca

Authors 

Young-Hee KimIn Ja RyooSoo-Jin ChooG H XuSangku LeeS J SeokK BaeIck Dong Yoo

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2009

Citation 

Journal of Microbiology and Biotechnology, vol. 19, no. 10, pp. 1139-1141

Keywords 

Clitocybe aurantiacaClitocybin DHuman neutrophil elastase

Abstract 

Clitocybin D, a novel human neutrophil elastase inhibitor, was isolated from the culture broth of Clitocybe aurantiaca. This compound was purified by solvent extraction, silica gel column chromatography, Sephadex LH-20 column chromatography, and preparative HPLC. The compound was determined to be 4-(4,6-dihydroxy-3-methoxy-3Hisoindol-1-yl)-benzoic acid on the basis of 1D and 2D NMRs and MS spectroscopic analysis. Analysis of the human neutrophil elastase (HNE) inhibitory activity of the isolated compound revealed that it showed significant HNE inhibitory activity with an IC50 value of 17.8 μM.

ISSN 

1017-7825

Link 

http://dx.doi.org/10.4014/jmb.0903.03033

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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