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Title 

Post-transcriptional regulation of NK cell activation

Authors 

Tae-Don KimJu-Young ParkIn Pyo Choi

Issue Date 

2009

Citation 

Immune Network, vol. 9, no. 4, pp. 115-121

Abstract 

Natural killer (NK) cells play key roles in innate and adaptive immune defenses. NK cell responses are mediated by two major mechanisms: the direct cytolysis of target cells, and immune regulation by production of various cytokines. Many previous reports show that the complex NK cell activation process requires de novo gene expression regulated at both transcriptional and post-transcriptional levels. Specialized un-translated regions (UTR) of mRNAs are the main mechanisms of post-transcriptional regulation. Analysis of post-transcriptional regulation is needed to clearly understand NK cell biology and, furthermore, harness the power of NK cells for therapeutic aims. This review summarizes the current understanding of mRNA metabolism during NK cell activation, focusing primarily on post-transcriptional regulation.

ISSN 

1598-2629

Link 

http://dx.doi.org/10.4110/in.2009.9.4.115

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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