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Title 

Evidence against the physiological role of acetyl phosphate in the phosphorylation of the ArcA response regulator in Escherichia coli

Authors 

X LiuG R P SandovalB L WannerW S JungD GeorgellisOh Suk Kwon

Publisher 

Microbiological Society of Korea

Issue Date 

2009

Citation 

Journal of Microbiology, vol. 47, no. 5, pp. 657-662

Keywords 

Acetyl phosphateArc two-component signal transductionArcA response regulatorE. coli

Abstract 

The Arc two-component signal transduction system of Escherichia coli comprises the ArcB sensor kinase and the ArcA response regulator. Under anoxic growth conditions, ArcB autophosphorylates and transphos-phorylates ArcA, which, in turn, represses or activates its target operons. ArcA has been shown to be able to autophosphorylate in vitro at the expense of acetyl-P. Here, the in vivo effect of acetyl phosphate on the redox signal transduction by the Arc system was assessed. Our results indicate that acetyl phosphate can modulate the expression of ArcA-P target genes only in the absence of ArcB. Therefore, the acetyl phosphate dependent ArcA phosphorylation route does not seem to play a significant role under physiological conditions.

ISSN 

1225-8873

Link 

http://dx.doi.org/10.1007/s12275-009-0087-9

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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