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Title 

Influence of basic residues on dissociation kinetics and dynamics of singly protonated peptides: Time-resolved photodissociation study

Authors 

S H YoonJeong Hee MoonY J ChungM S Kim

Publisher 

Wiley-Blackwell

Issue Date 

2009

Citation 

Journal of Mass Spectrometry, vol. 44, no. 10, pp. 1532-1537

Keywords 

Dissociation kinetics and dynamicsDissociation rate constantPeptide dissociationPhotodissociationRRKMTandem TOFTime-resolved study

Abstract 

Product ion yields in postsource decay and time-resolved photodissociation at 193 and 266 nm were measured for some peptide ions with lysine ([KF 6 + H]+, [F6K + H]+, and [F 3KF3 + H]+) formed by matrix-assisted laser desorption ionization. The critical energy (E0) and entropy (ΔS‡) were determined by RRKM fitting of the data. The results were similar to those found previously for peptide ions with histidine. To summarize, the presence of a basic residue, histidine or lysine, inside a peptide ion retarded its dissociation by lowering ΔS‡. On the basis of highly negative ΔS‡, presence of intramolecular interaction involving a basic group in the transition structure was proposed.

ISSN 

1076-5174

Link 

http://dx.doi.org/10.1002/jms.1670

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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