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Title 

Viral interferon regulatory factors

Authors 

H R LeeMyung Hee KimJ S LeeC LiangJ U Jung

Publisher 

Mary Ann Liebert

Issue Date 

2009

Citation 

Journal of Interferon and Cytokine Research, vol. 29, no. 9, pp. 621-627

Abstract 

Upon viral infection, the major defensive strategy employed by the host immune system is the activation of the interferon (IFN)-mediated antiviral pathway, which is overseen by IFN regulatory factors (IRFs). In order to complete their life cycles, viruses must find a way to modulate the host IFN-mediated immune response. Kaposi's sarcoma-associated herpesvirus (KSHV), a human tumor-inducing herpesvirus, has developed a unique mechanism for antagonizing cellular IFN-mediated antiviral activity by incorporating viral homolog of the cellular IRFs, called vIRFs, into its genome. Here, we summarize the novel evasion mechanisms by which KSHV, through its vIRFs, circumvents IFN-mediated innate immune responses and deregulates the cell growth control mechanism.

ISSN 

1079-9907

Link 

http://dx.doi.org/10.1089/jir.2009.0067.

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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