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Title 

Comparative study on inhibitory activity of zerumbone and zerumbone 2,3-epoxide on NF-κB activation and NO production

Authors 

P M GiangP T SonH Z JinJ H LeeJung Joon Lee

Publisher 

?sterreichischer Apothekerverlag

Issue Date 

2009

Citation 

Scientia Pharmaceutica, vol. 77, no. 3, pp. 589-595

Keywords 

NF-κBNO productionZerumboneZerumbone-2,3-epoxide

Abstract 

In the present study the significant role of the α,β-unsaturated carbonyl structure in the anti-inflammatory activity of the natural humulane sesquiterpenoids zerumbone and zerumbone 2,3-epoxide was evidenced from a comparative study of the ability of zerumbone and zerumbone 2,3-epoxide to inhibit NF-κB activation and NO production in LPS (lipopolysaccharide)- stimulated RAW 264.7 cells. The IC50 of these compounds were 1.97 μM ± 0.18 and 30.11 μM ± 4.10 in the NF-κB activation assay and 3.58 μM ± 0.46 and 34.7 μM ± 3.72 in the nitric oxide production assay, respectively.

ISSN 

0036-8709

Link 

http://dx.doi.org/10.3797/scipharm.0907-16

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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