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Title 

Genome evolution and adaptation in a long-term experiment with Escherichia coli

Authors 

J E BarrickDong Su YuSung Ho YoonHaeyoung JeongTae Kwang OhD SchneiderR E LenskiJihyun Kim

Publisher 

Nature Publishing Group

Issue Date 

2009

Citation 

Nature, vol. 461, no. 7268, pp. 1243-1247

Abstract 

The relationship between rates of genomic evolution and organismal adaptation remains uncertain, despite considerable interest. The feasibility of obtaining genome sequences from experimentally evolving populations offers the opportunity to investigate this relationship with new precision. Here we sequence genomes sampled through 40,000 generations from a laboratory population of Escherichia coli. Although adaptation decelerated sharply, genomic evolution was nearly constant for 20,000 generations. Such clock-like regularity is usually viewed as the signature of neutral evolution, but several lines of evidence indicate that almost all of these mutations were beneficial. This same population later evolved an elevated mutation rate and accumulated hundreds of additional mutations dominated by a neutral signature. Thus, the coupling between genomic and adaptive evolution is complex and can be counterintuitive even in a constant environment. In particular, beneficial substitutions were surprisingly uniform over time, whereas neutral substitutions were highly variable.

ISSN 

0028-0836

Link 

http://dx.doi.org/10.1038/nature08480

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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