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Title 

Two new stereoisomers of neolignan and lignan from the flower buds of Magnolia fargesii

Authors 

J LeeE K SeoD S JangT J HaJong Pyung KimJ W NamG BaeY M LeeM S YangJ S Kim

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2009

Citation 

Chemical & Pharmaceutical Bulletin, vol. 57, no. 3, pp. 298-301

Keywords 

Aldose reductaseDiabetic complicationLignanMagnolia fargesiiSuperoxide radical

Abstract 

A new stereoisomer of 8-O-4′ system neolignan, (7R,8S)-1-(3,4- dimethoxyphenyl)-2-[4-(3-hydroxy-1-propenyl)-2-methoxyphenoxy]-propane-1,3-diol (1) and a new stereoisomer of tetrahydrofuranoid lignan, (7R,8S,7'S,8'R)-(3,4,5, 3′,4′)-pentamethoxy-9,7′-dihydroxy-8.8′,7.0. 9′-lignan (2) along with seven known lignans and neolignans (3-9) were isolated from the methanol extracts of the flower buds of Magnolia fargesii. The structures of these compounds (1-9) were elucidated by spectroscopic methods including 1D- and 2D-NMR as well as by comparison with reported values. Absolute configurations of new stereoisomers 1 and 2 were determined by circular dichroism (CD) spectra. The absolute configuration of (S,8S,10S)-[tetrahydro-4- hydroxy-2-(3,4,5-tri-methoxyphenyl)furan-3-yl]methyl 3,4-dimethoxy benzoate (3) was determined by Mosher's esterification method for the first time in this study. Three lignans, tanegool (4), (+)-dehydrodiconiferyl alcohol (5), and epieudes-min (6), were isolated from this plant for the first time. Superoxide radical scavenging activities of the isolates (1-9) were measured by irradiated riboflavin/ethylenediaminetetraacetic acid (EDTA)/Nitroblue tetrazolium (NBT) system, and their in vitro rat lens aldose reductase (RLAR) inhibitory activities were also evaluated.

ISSN 

0009-2363

Link 

http://dx.doi.org/10.1248/cpb.57.298

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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