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Title 

Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse

Authors 

S OhD LeeT KimT S KimH J OhChae Young HwangY Y KongKi Sun KwonD S Lim

Publisher 

American Society for Microbiology

Issue Date 

2009

Citation 

Molecular and Cellular Biology, vol. 29, no. 23, pp. 6309-6320

Abstract 

Mammalian sterile 20-like kinases 1 and 2 (Mst1 and Mst2, respectively) are potent serine/threonine kinases that are involved in cell proliferation and cell death. To investigate the physiological functions of Mst1 and Mst2, we generated Mst1 and Mst2 mutant mice. Mst1-/- and Mst2-/- mice were viable and fertile and developed normally, suggesting possible functional overlaps between the two genes. A characterization of heterozygous and homozygous combinations of Mst1 and Mst2 mutant mice showed that mice containing a single copy of either gene underwent normal organ development; however, Mst1-/-; Mst2-/- mice lacking both Mst1 and Mst2 genes started dying in utero at approximately embryonic day 8.5. Mst1 -/-; Mst2-/- mice exhibited severe growth retardation, failed placental development, impaired yolk sac/embryo vascular patterning and primitive hematopoiesis, increased apoptosis in placentas and embryos, and disorganized proliferating cells in the embryo proper. These findings indicate that both Mst1 and Mst2 kinases play essential roles in early mouse development, regulating placental development, vascular patterning, primitive hematopoiesis, and cell proliferation and survival.

ISSN 

0270-7306

Link 

http://dx.doi.org/10.1128/MCB.00551-09

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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