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Title 

Mapping human genetic diversity in asia

 

인류의 유전적다양성 지도

Authors 

M A AbdullaI AhmedA AssawamakinJ BhakS K BrahmachariG C CalacalHo-Young KangL JinJ JungH L KimK KimS KimWoo Yeon KimK KimmJ Y LeeSung Hoon LeeE T LiuSang Ho OhM SeielstadS XuJin Ok YangHyang Sook YooB A ZilfalilIndian Genome Varia ConsortiumHUGO Pan-Asian SNP Consortium

Publisher 

American Association for the Advancement of Science

Issue Date 

2009

Citation 

Science, vol. 326, no. 5959, pp. 1541-1545

Abstract 

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

ISSN 

0036-8075

Link 

http://dx.doi.org/10.1126/science.1177074

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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