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Title 

Steroids and triterpenes from the fruit bodies of Ganoderma lucidum and their anti-complement activity

Authors 

H W SeoT M HungM NaH J JungJ C KimJ S ChoiJung Hee KimHyeong Kyu LeeI LeeK BaeM HattoriB S Min

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2009

Citation 

Archives of Pharmacal Research, vol. 32, no. 11, pp. 1573-1579

Keywords 

Anti-complementary activityGanoderic acid SzGanoderma lucidumLanostadiene triterpenePolyporaceae

Abstract 

To determine the anti-complement activity of natural triterpenes, chromatographic separation of the EtOAc-soluble fraction from the fruiting body of Ganoderma lucidum led to the isolation of three steroids and five triterpenoids. They were identified as ergosterol peroxide (1), ergosterol (2), genoderic acid Sz (3), stella sterol (4), ganoderic aic C1 (5), ganoderic acid A (6), methyl ganoderate A (7), and lucidenic acid A (8) based on spectroscopic evidence and physicochemical properties. These compounds were examined for their anti-complement activity against the classical pathway of the complement system. Compounds 2 and 3 showed potent anti-complement activity with IC 50 values of 52.0 and 44.6 μM, respectively. Compound 1 exhibited significant inhibitory activity with an IC50 value of 126.8 μM, whereas compounds 4-8 were inactive. Our findings suggested that in addition to the ketone group at C-3, the Δ7(8), Δ9(11)- lanostadiene type triterpene also plays an important role in inhibiting the hemolytic activity of human serum against erythrocytes.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-009-2109-x

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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